SOT (Supportive Oligonucleotide Technique)

DNA strand

What is SOT Therapy?

SOT is a type of therapy based on antisense oligonucleotide technique (ASOT) that is a technology that is being utilized and studied in various diseases, including cancer.

SOT is now being used as a treatment for Lyme bacteria, co-infections, and viruses like EBV, HSV, CMV, Varicella and others. This breakthrough therapy utilizes short DNA or RNA segments to block the expression of critical segments of genes needed for certain microbes to survive and replicate.

SOT creates a shutoff “key” that precisely fits a chosen “lock” portion of a pathogen. The “lock” is a specific section of DNA that normally controls an important function of the pathogen. The “key” binds to the “lock” and blocks the function thus eliminating the pathogen. Afterwards, the SOT compound is released and travels to the next target, thus fighting the infection 24/7 for up to 6 months.

SOT works by creating a short segment of mRNA in the lab that binds to the specific DNA segments and prevents the bacteria from making essential proteins, essentially shutting off bacterial replication. Unable to replicate, the bacteria is unable to cause disease.

What is the process for getting SOT, from start to finish?

  • Specialized blood testing will be done in our office to confirm the presence of a specific infection or co-infection.
  • Upon reviewing the results with you, your doctor will then decide which pathogen to order SOT for.
  • Your blood is then drawn again in our office to be sent to the RGCC laboratory in Greece.
  • After about 4 weeks, your oligonucleotide molecules (SOT) will arrive in our office and you will return to have your SOT administered intravenously. The SOT infusion takes approximately 2 hours.
  • Six weeks after SOT, co-infections may flare and retesting with your doctor may need to be done. Six months post-SOT, additional lab testing will be done to see how you are progressing.

The main side effects of SOT treatment are detox or “Herx” reactions, such as fatigue, body aches, and headache. Some patients experience no side effects but others will have mild to moderate reactions and the onset of these reactions varies from patient to patient.

The SOT for a particular infection may be repeated up to 3x per year if needed. With each round of SOT it is recommended to retest for the presence of other pathogens. At some point the infection may be completely eradicated or remain stable in a quiet remission.

What pathogens does SOT target?



  • B.afzelii
  • B.bissettii
  • B.bavariensis
  • B.burgdorferi
  • B.californiesis
  • B.finlandensis
  • B.garinii
  • B.genomospecies
  • B.hermsii
  • B.kurtenbachii
  • B.lusitaniae
  • B.mayonii
  • B.miyamotoi
  • B.recurrentis
  • B.sinica
  • B.turcica
  • B.valaisiana
  • Candidatus B.tachyglossi
  • B.valaisiana


  • B.bacilliformis
  • B.elizabethae
  • B.henselae
  • B.koehlerae
  • B.quintana
  • B.vinsonii


  • B.bigemina
  • B.bovis
  • B.divergens
  • B.duncani
  • B.microti
  • B.odocoilei

Other tick-borne bacteria

  • Anaplasma phagocytophilum
  • Ehrlichia chaffeensis
  • Rickettsia rickettsia


  • HHV1/HSV1 — (Human Simplex Virus-Oral-Facial)
  • HHV2/HSV2 — (Human Simplex Virus-Genital)
  • HHV6 (A & B) — (Human Herpes Virus 6)
  • CMV — (Cytomegalovirus)
  • Coxsackie (Type A & B)
  • VZV — Varicella-zoster (shingles)
  • EBV — (Epstein Barr)
  • HPV (16/18) — Human papillomavirus
  • HPV (6/11) — Human papillomavirus
  • HBV — (hepatitis B)
  • HCV — (hepatitis C)
  • HIV — (human immunodeficiency virus)-AIDS
  • HTLV1— (human T-cell lymphotropic virus)

How is SOT administered, and how long does it take?

The molecules are put into the body via an IV push that takes approximately 5 minutes. The entire process takes about 90-120 minutes because saline is also administered via an IV along with an antihistamine and steroids. You are watched in the clinic for approximately 2 hours to be sure there are no side-effects.

treatment room

Did you know?

SOT is not a drug in the traditional sense. It is not an antibiotic nor is it gene therapy. It does not change the genetic structure. There is no gene splicing, gene insertion, or manipulation.

SOT therapy is a stealth technology with molecules so small that they are able to avoid detection and destruction by the immune system or RNA degrading enzymes for months, allowing them to quietly circulate through the body, attaching to their viral or bacterial targets.